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Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins

To achieve swift cell demise during apoptosis, caspases cleave essential proteins for cell survival and removal. In addition to the binding of preferred amino acid sequences to its substrate-binding pocket, caspase-7 also uses exosites to select specific substrates. 4 lysine residues (K(38)KKK) loca...

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Detalles Bibliográficos
Autores principales: Desroches, Alexandre, Denault, Jean-Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815152/
https://www.ncbi.nlm.nih.gov/pubmed/31586028
http://dx.doi.org/10.1073/pnas.1909283116