Cargando…

Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus

The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrP(C)). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein (PrP(Sc)), levels of mature endogenous Sho become reduced. To study the regulatory ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Sang-Gyun, Mays, Charles E., Daude, Nathalie, Yang, Jing, Kar, Satyabrata, Westaway, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815274/ https://www.ncbi.nlm.nih.gov/pubmed/31129810 http://dx.doi.org/10.1007/s12035-019-1623-1

Ejemplares similares

Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia
por: Daude, Nathalie, et al.
Publicado: (2015)

Shadoo/PrP (Sprn(0/0)/Prnp(0/0)) double knockout mice: More than zeroes
por: Daude, Nathalie, et al.
Publicado: (2012)

Frequent Missense and Insertion/Deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-Specific Variation in PrP
por: Daude, Nathalie, et al.
Publicado: (2009)

Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrP(Sc) Accumulation
por: Westaway, David, et al.
Publicado: (2011)

The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections
por: Watts, Joel C, et al.
Publicado: (2007)

Quaternary Structure Changes for PrP(Sc) Predate PrP(C) Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease
por: Eskandari-Sedighi, Ghazaleh, et al.
Publicado: (2020)

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice
por: Eigenbrod, Sabina, et al.
Publicado: (2017)

Interactome Analyses Identify Ties of PrP(C) and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones
por: Watts, Joel C., et al.
Publicado: (2009)

The Prion-like protein Shadoo is involved in mouse embryonic and mammary development and differentiation
por: Passet, Bruno, et al.
Publicado: (2020)

Correction: Interactome Analyses Identify Ties of PrP(C) and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones
por: Watts, Joel C., et al.
Publicado: (2009)

Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo
por: Pepe, Anna, et al.
Publicado: (2017)

PrP Expression, PrP(Sc) Accumulation and Innervation of Splenic Compartments in Sheep Experimentally Infected with Scrapie
por: Sørby, Randi, et al.
Publicado: (2009)

Mice Treated Subcutaneously with Mouse LPS-Converted PrP(res) or LPS Alone Showed Brain Gene Expression Profiles Characteristic of Prion Disease
por: Hailemariam, Dagnachew, et al.
Publicado: (2021)

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer
por: Pocanschi, Cosmin L., et al.
Publicado: (2013)

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015)

Shadoo (Sprn) and prion disease incubation time in mice
por: Lloyd, Sarah E., et al.
Publicado: (2009)

Protease-Resistant Prions Selectively Decrease Shadoo Protein
por: Watts, Joel C., et al.
Publicado: (2011)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
por: Honda, Ryo P., et al.
Publicado: (2017)

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles
por: Mercer, Robert C. C., et al.
Publicado: (2018)

Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction
por: Quaglio, Elena, et al.
Publicado: (2011)

The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

Predicting the consequences of selecting on PrP genotypes on PrP frequencies, performance and inbreeding in commercial meat sheep populations
por: Man, Wing-Young N, et al.
Publicado: (2007)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Identification of the RGG Box Motif in Shadoo: RNA-Binding and Signaling Roles?
por: Corley, Susan M., et al.
Publicado: (2008)

Prion Protein and Shadoo Are Involved in Overlapping Embryonic Pathways and Trophoblastic Development
por: Passet, Bruno, et al.
Publicado: (2012)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
por: Barron, Rona M., et al.
Publicado: (2016)

Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis
por: Sevillano, Alejandro M., et al.
Publicado: (2018)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie
por: Sarradin, Pierre, et al.
Publicado: (2015)

Na(+)/K(+)-ATPase Is Present in Scrapie-Associated Fibrils, Modulates PrP Misfolding In Vitro and Links PrP Function and Dysfunction
por: Graham, James F., et al.
Publicado: (2011)

Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics
por: Jetha, Nahid N., et al.
Publicado: (2013)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2013)

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrP(res) in heterozygous scrapie positive goats
por: Mazza, Maria, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5isg6ukmlllc26lojhuqtlt0l0