Cargando…
Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
OBJECTIVE: To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth in non-small-cell lung cancer (NSCLC). METHODS: The correlation of p53 and pyroptosis was determined in tumor tissues of NSCLC patients. The pyroptotic level was detected in A549 cells to clarify the effec...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815571/ https://www.ncbi.nlm.nih.gov/pubmed/31737176 http://dx.doi.org/10.1155/2019/8746895 |
_version_ | 1783463213358120960 |
---|---|
author | Zhang, Tianze Li, Yongchao Zhu, Ruidong Song, Pengcheng Wei, Youlei Liang, Tian Xu, Guangquan |
author_facet | Zhang, Tianze Li, Yongchao Zhu, Ruidong Song, Pengcheng Wei, Youlei Liang, Tian Xu, Guangquan |
author_sort | Zhang, Tianze |
collection | PubMed |
description | OBJECTIVE: To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth in non-small-cell lung cancer (NSCLC). METHODS: The correlation of p53 and pyroptosis was determined in tumor tissues of NSCLC patients. The pyroptotic level was detected in A549 cells to clarify the effect of p53 on pyroptosis. p53 overexpression A549 tumor-bearing mice were used to clarify the therapeutic target of p53 in NSCLC treatment. RESULTS: p53 expression level was positively related to pyroptosis in NSCLC tissues. In in vitro assays, p53 directly regulated pyroptosis in A549 cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced pyroptosis. In in vivo assays, p53 overexpression in A549 markedly decreased tumor growth and death rate by increasing the pyroptotic level. CONCLUSIONS: Upregulation of p53 prompts pyroptosis to produce anti-NSCLC effects suggesting the potential of p53 on suppressing tumor growth in NSCLC patients. |
format | Online Article Text |
id | pubmed-6815571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-68155712019-11-17 Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer Zhang, Tianze Li, Yongchao Zhu, Ruidong Song, Pengcheng Wei, Youlei Liang, Tian Xu, Guangquan Oxid Med Cell Longev Research Article OBJECTIVE: To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth in non-small-cell lung cancer (NSCLC). METHODS: The correlation of p53 and pyroptosis was determined in tumor tissues of NSCLC patients. The pyroptotic level was detected in A549 cells to clarify the effect of p53 on pyroptosis. p53 overexpression A549 tumor-bearing mice were used to clarify the therapeutic target of p53 in NSCLC treatment. RESULTS: p53 expression level was positively related to pyroptosis in NSCLC tissues. In in vitro assays, p53 directly regulated pyroptosis in A549 cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced pyroptosis. In in vivo assays, p53 overexpression in A549 markedly decreased tumor growth and death rate by increasing the pyroptotic level. CONCLUSIONS: Upregulation of p53 prompts pyroptosis to produce anti-NSCLC effects suggesting the potential of p53 on suppressing tumor growth in NSCLC patients. Hindawi 2019-10-13 /pmc/articles/PMC6815571/ /pubmed/31737176 http://dx.doi.org/10.1155/2019/8746895 Text en Copyright © 2019 Tianze Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Tianze Li, Yongchao Zhu, Ruidong Song, Pengcheng Wei, Youlei Liang, Tian Xu, Guangquan Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer |
title | Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer |
title_full | Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer |
title_fullStr | Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer |
title_full_unstemmed | Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer |
title_short | Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer |
title_sort | transcription factor p53 suppresses tumor growth by prompting pyroptosis in non-small-cell lung cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815571/ https://www.ncbi.nlm.nih.gov/pubmed/31737176 http://dx.doi.org/10.1155/2019/8746895 |
work_keys_str_mv | AT zhangtianze transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer AT liyongchao transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer AT zhuruidong transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer AT songpengcheng transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer AT weiyoulei transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer AT liangtian transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer AT xuguangquan transcriptionfactorp53suppressestumorgrowthbypromptingpyroptosisinnonsmallcelllungcancer |