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Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer

OBJECTIVE: To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth in non-small-cell lung cancer (NSCLC). METHODS: The correlation of p53 and pyroptosis was determined in tumor tissues of NSCLC patients. The pyroptotic level was detected in A549 cells to clarify the effec...

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Autores principales: Zhang, Tianze, Li, Yongchao, Zhu, Ruidong, Song, Pengcheng, Wei, Youlei, Liang, Tian, Xu, Guangquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815571/
https://www.ncbi.nlm.nih.gov/pubmed/31737176
http://dx.doi.org/10.1155/2019/8746895
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author Zhang, Tianze
Li, Yongchao
Zhu, Ruidong
Song, Pengcheng
Wei, Youlei
Liang, Tian
Xu, Guangquan
author_facet Zhang, Tianze
Li, Yongchao
Zhu, Ruidong
Song, Pengcheng
Wei, Youlei
Liang, Tian
Xu, Guangquan
author_sort Zhang, Tianze
collection PubMed
description OBJECTIVE: To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth in non-small-cell lung cancer (NSCLC). METHODS: The correlation of p53 and pyroptosis was determined in tumor tissues of NSCLC patients. The pyroptotic level was detected in A549 cells to clarify the effect of p53 on pyroptosis. p53 overexpression A549 tumor-bearing mice were used to clarify the therapeutic target of p53 in NSCLC treatment. RESULTS: p53 expression level was positively related to pyroptosis in NSCLC tissues. In in vitro assays, p53 directly regulated pyroptosis in A549 cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced pyroptosis. In in vivo assays, p53 overexpression in A549 markedly decreased tumor growth and death rate by increasing the pyroptotic level. CONCLUSIONS: Upregulation of p53 prompts pyroptosis to produce anti-NSCLC effects suggesting the potential of p53 on suppressing tumor growth in NSCLC patients.
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spelling pubmed-68155712019-11-17 Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer Zhang, Tianze Li, Yongchao Zhu, Ruidong Song, Pengcheng Wei, Youlei Liang, Tian Xu, Guangquan Oxid Med Cell Longev Research Article OBJECTIVE: To evaluate the effect of p53 on pyroptosis and its inhibitory role on tumor growth in non-small-cell lung cancer (NSCLC). METHODS: The correlation of p53 and pyroptosis was determined in tumor tissues of NSCLC patients. The pyroptotic level was detected in A549 cells to clarify the effect of p53 on pyroptosis. p53 overexpression A549 tumor-bearing mice were used to clarify the therapeutic target of p53 in NSCLC treatment. RESULTS: p53 expression level was positively related to pyroptosis in NSCLC tissues. In in vitro assays, p53 directly regulated pyroptosis in A549 cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced pyroptosis. In in vivo assays, p53 overexpression in A549 markedly decreased tumor growth and death rate by increasing the pyroptotic level. CONCLUSIONS: Upregulation of p53 prompts pyroptosis to produce anti-NSCLC effects suggesting the potential of p53 on suppressing tumor growth in NSCLC patients. Hindawi 2019-10-13 /pmc/articles/PMC6815571/ /pubmed/31737176 http://dx.doi.org/10.1155/2019/8746895 Text en Copyright © 2019 Tianze Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Tianze
Li, Yongchao
Zhu, Ruidong
Song, Pengcheng
Wei, Youlei
Liang, Tian
Xu, Guangquan
Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
title Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
title_full Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
title_fullStr Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
title_full_unstemmed Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
title_short Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer
title_sort transcription factor p53 suppresses tumor growth by prompting pyroptosis in non-small-cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815571/
https://www.ncbi.nlm.nih.gov/pubmed/31737176
http://dx.doi.org/10.1155/2019/8746895
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