Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

Matrine, an alkaloid isolated from Sophora flavescens, possesses a wide range of pharmacological properties. However, the use of matrine in clinical practice is limited due to its toxic effects. The present study investigated the roles of mitochondria and reactive oxygen species (ROS) in matrine-ind...

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Detalles Bibliográficos
Autores principales: You, Longtai, Yang, Chunjing, Du, Yuanyuan, Liu, Yi, Chen, Gongsen, Sai, Na, Dong, Xiaoxv, Yin, Xingbin, Ni, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815593/
https://www.ncbi.nlm.nih.gov/pubmed/31737162
http://dx.doi.org/10.1155/2019/1045345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815593/
https://www.ncbi.nlm.nih.gov/pubmed/31737162
http://dx.doi.org/10.1155/2019/1045345

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