Losartan Reverses Hippocampal Increase of Kynurenic Acid in Type 1 Diabetic Rats: A Novel Procognitive Aspect of Sartan Action

Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood. Kynurenic acid (KYNA), endogenous kynurenine metabolite, displays pleiotropic effects, including a blockade of glutamatergic and cholinerg...

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Detalles Bibliográficos
Autores principales: Chmiel-Perzyńska, Iwona, Perzyński, Adam, Olajossy, Bartosz, Gil-Kulik, Paulina, Kocki, Janusz, Urbańska, Ewa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815597/
https://www.ncbi.nlm.nih.gov/pubmed/31737685
http://dx.doi.org/10.1155/2019/4957879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815597/
https://www.ncbi.nlm.nih.gov/pubmed/31737685
http://dx.doi.org/10.1155/2019/4957879

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