MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition

Mitochondrial dynamic disorder is involved in myocardial ischemia/reperfusion (I/R) injury. To explore the effect of mitochondrial calcium uniporter (MCU) on mitochondrial dynamic imbalance under I/R and its related signal pathways, a mouse myocardial I/R model and hypoxia/reoxygenation model of mou...

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Detalles Bibliográficos
Autores principales: Guan, Lichun, Che, Zhimei, Meng, Xiangdong, Yu, Yong, Li, Minghui, Yu, Ziqin, Shi, Hui, Yang, Dicheng, Yu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815825/
https://www.ncbi.nlm.nih.gov/pubmed/31502361
http://dx.doi.org/10.1111/jcmm.14662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815825/
https://www.ncbi.nlm.nih.gov/pubmed/31502361
http://dx.doi.org/10.1111/jcmm.14662

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