Iron chelation and 2‐oxoglutarate‐dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1

The patients with mantle cell lymphoma (MCL) have translocation t(11;14) associated with cyclin D1 overexpression. We observed that iron (an essential cofactor of dioxygenases including prolyl hydroxylases [PHDs]) depletion by deferoxamine blocked MCL cells’ proliferation, increased expression of DN...

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Detalles Bibliográficos
Autores principales: Babosova, Olga, Kapralova, Katarina, Raskova Kafkova, Leona, Korinek, Vladimir, Divoky, Vladimir, Prchal, Josef T., Lanikova, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815829/
https://www.ncbi.nlm.nih.gov/pubmed/31517438
http://dx.doi.org/10.1111/jcmm.14655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815829/
https://www.ncbi.nlm.nih.gov/pubmed/31517438
http://dx.doi.org/10.1111/jcmm.14655

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