Ultrasound and Microbubble-targeted Delivery of a microRNA Inhibitor to the Heart Suppresses Cardiac Hypertrophy and Preserves Cardiac Function

MicroRNAs (miRs) are dysregulated in pathological left ventricular hypertrophy. AntimiR inhibition of miR-23a suppressed hypertension-induced cardiac hypertrophy in preclinical models, but clinical translation is limited by a lack of cardiac-targeted delivery systems. Ultrasound-targeted microbubble...

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Detalles Bibliográficos
Autores principales: Kopechek, Jonathan A., McTiernan, Charles F., Chen, Xucai, Zhu, Jianhui, Mburu, Maureen, Feroze, Rafey, Whitehurst, Daniel A., Lavery, Linda, Cyriac, Jissy, Villanueva, Flordeliza S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815962/
https://www.ncbi.nlm.nih.gov/pubmed/31660088
http://dx.doi.org/10.7150/thno.34895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815962/
https://www.ncbi.nlm.nih.gov/pubmed/31660088
http://dx.doi.org/10.7150/thno.34895

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