The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

BACKGROUND: Patients with pre-existing neurodegenerative disease commonly experience fractures that require orthopedic surgery. Perioperative neurocognitive disorders (PND), including delirium and postoperative cognitive dysfunction, are serious complications that can result in increased 1-year mort...

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Detalles Bibliográficos
Autores principales: Miller-Rhodes, Patrick, Kong, Cuicui, Baht, Gurpreet S., Saminathan, Priyanka, Rodriguiz, Ramona M., Wetsel, William C., Gelbard, Harris A., Terrando, Niccolò
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816182/
https://www.ncbi.nlm.nih.gov/pubmed/31660984
http://dx.doi.org/10.1186/s12974-019-1582-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816182/
https://www.ncbi.nlm.nih.gov/pubmed/31660984
http://dx.doi.org/10.1186/s12974-019-1582-5

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