A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography

PURPOSE: The purpose of this study was to develop a SIRT2-specific substrate-type radiotracer for non-invasive PET imaging of epigenetic regulatory processes mediated by SIRT2 in normal and disease tissues. PROCEDURES: A library of compounds containing tert-butyloxycarbonyl-lysineaminomethylcoumarin...

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Detalles Bibliográficos
Autores principales: Bonomi, Robin E., Laws, Maxwell, Popov, Vadim, Kamal, Swatabdi, Potukutchi, Shreya, Shavrin, Aleksandr, Lu, Xin, Turkman, Nashaat, Liu, Ren-Shyan, Mangner, Thomas, Gelovani, Juri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816246/
https://www.ncbi.nlm.nih.gov/pubmed/29423902
http://dx.doi.org/10.1007/s11307-017-1149-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816246/
https://www.ncbi.nlm.nih.gov/pubmed/29423902
http://dx.doi.org/10.1007/s11307-017-1149-8

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