Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structu...

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Detalles Bibliográficos
Autores principales: Bosshart, Patrick D., Kalbermatter, David, Bonetti, Sara, Fotiadis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816346/
https://www.ncbi.nlm.nih.gov/pubmed/31692891
http://dx.doi.org/10.1080/23723556.2019.1646605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816346/
https://www.ncbi.nlm.nih.gov/pubmed/31692891
http://dx.doi.org/10.1080/23723556.2019.1646605

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