Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structu...

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Detalles Bibliográficos
Autores principales: Bosshart, Patrick D., Kalbermatter, David, Bonetti, Sara, Fotiadis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816346/
https://www.ncbi.nlm.nih.gov/pubmed/31692891
http://dx.doi.org/10.1080/23723556.2019.1646605
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author Bosshart, Patrick D.
Kalbermatter, David
Bonetti, Sara
Fotiadis, Dimitrios
author_facet Bosshart, Patrick D.
Kalbermatter, David
Bonetti, Sara
Fotiadis, Dimitrios
author_sort Bosshart, Patrick D.
collection PubMed
description Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure–function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport.
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spelling pubmed-68163462020-08-27 Structure and function of a monocarboxylate transporter homolog specific for L-lactate Bosshart, Patrick D. Kalbermatter, David Bonetti, Sara Fotiadis, Dimitrios Mol Cell Oncol Author’s View Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure–function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport. Taylor & Francis 2019-08-27 /pmc/articles/PMC6816346/ /pubmed/31692891 http://dx.doi.org/10.1080/23723556.2019.1646605 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s View
Bosshart, Patrick D.
Kalbermatter, David
Bonetti, Sara
Fotiadis, Dimitrios
Structure and function of a monocarboxylate transporter homolog specific for L-lactate
title Structure and function of a monocarboxylate transporter homolog specific for L-lactate
title_full Structure and function of a monocarboxylate transporter homolog specific for L-lactate
title_fullStr Structure and function of a monocarboxylate transporter homolog specific for L-lactate
title_full_unstemmed Structure and function of a monocarboxylate transporter homolog specific for L-lactate
title_short Structure and function of a monocarboxylate transporter homolog specific for L-lactate
title_sort structure and function of a monocarboxylate transporter homolog specific for l-lactate
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816346/
https://www.ncbi.nlm.nih.gov/pubmed/31692891
http://dx.doi.org/10.1080/23723556.2019.1646605
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