Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cells

Antibody engineering in mammalian cells offers the important advantage of expression and screening of libraries in their native conformation, increasing the likelihood of generating candidates with more favorable molecular properties. Major advances in cellular engineering enabled by CRISPR-Cas9 gen...

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Detalles Bibliográficos
Autores principales: Parola, Cristina, Neumeier, Daniel, Friedensohn, Simon, Csepregi, Lucia, Di Tacchio, Mariangela, Mason, Derek M., Reddy, Sai T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816377/
https://www.ncbi.nlm.nih.gov/pubmed/31478465
http://dx.doi.org/10.1080/19420862.2019.1662691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816377/
https://www.ncbi.nlm.nih.gov/pubmed/31478465
http://dx.doi.org/10.1080/19420862.2019.1662691

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