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Segregation of the mouse germline and soma

Mouse primordial germ cells (PGCs), originate from the early post-implantation epiblast in response to BMP4 secreted by the extraembryonic ectoderm. However, how BMP4 acts here has remained unclear. Recent work has identified the transcription factor (TF), OTX2 as a key determinant of the segregatio...

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Detalles Bibliográficos
Autores principales: Zhang, Man, Chambers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816410/
https://www.ncbi.nlm.nih.gov/pubmed/31583942
http://dx.doi.org/10.1080/15384101.2019.1672466