Off-target effects of CRISPRa on interleukin-6 expression

Inactive fusion variants of the CRISPR-Cas9 system are increasingly being used as standard methodology to study transcription regulation. Their ability to readily manipulate the native genomic loci is particularly advantageous. In this work, we serendipitously uncover the key cytokine IL6 as an off-...

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Detalles Bibliográficos
Autores principales: Soubeyrand, Sébastien, Lau, Paulina, Peters, Victoria, McPherson, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816553/
https://www.ncbi.nlm.nih.gov/pubmed/31658298
http://dx.doi.org/10.1371/journal.pone.0224113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816553/
https://www.ncbi.nlm.nih.gov/pubmed/31658298
http://dx.doi.org/10.1371/journal.pone.0224113

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