Esophageal 3D organoids of MPV17(-/-) mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition

Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial genome (mtDNA) content in primary tumors correlates with poor patient prognosis. H...

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Detalles Bibliográficos
Autores principales: Guha, Manti, Srinivasan, Satish, Sheehan, Maura M., Kijima, Takashi, Ruthel, Gordon, Whelan, Kelly, Tanaka, Koji, Klein-Szanto, Andres, Chandramouleeswaran, Prasanna M., Nakagawa, Hiroshi, Avadhani, Narayan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817447/
https://www.ncbi.nlm.nih.gov/pubmed/31692873
http://dx.doi.org/10.18632/oncotarget.27264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817447/
https://www.ncbi.nlm.nih.gov/pubmed/31692873
http://dx.doi.org/10.18632/oncotarget.27264

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