Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity

Runs of homozygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes that are identical by descent. Their length distributions are informative about population history, and their genomic locations are useful for mapping recessive loci contributing to bot...

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Detalles Bibliográficos
Autores principales: Szpiech, Zachary A., Mak, Angel C.Y., White, Marquitta J., Hu, Donglei, Eng, Celeste, Burchard, Esteban G., Hernandez, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817522/
https://www.ncbi.nlm.nih.gov/pubmed/31543216
http://dx.doi.org/10.1016/j.ajhg.2019.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817522/
https://www.ncbi.nlm.nih.gov/pubmed/31543216
http://dx.doi.org/10.1016/j.ajhg.2019.08.011

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