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LncRNA AFAP1-AS1 Supresses miR-139-5p and Promotes Cell Proliferation and Chemotherapy Resistance of Non-small Cell Lung Cancer by Competitively Upregulating RRM2

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. This study aims to understand the underlying mechanism of lncRNA, actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1) in mediating chemotherapeutic resistance in NSCLC. The levels of AFAP1-AS1 in NS...

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Detalles Bibliográficos
Autores principales: Huang, Na, Guo, Wei, Ren, Ke, Li, Wancheng, Jiang, Yi, Sun, Jian, Dai, Wenjing, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817562/
https://www.ncbi.nlm.nih.gov/pubmed/31696057
http://dx.doi.org/10.3389/fonc.2019.01103