Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract

An environment-friendly and efficient method for simultaneous determination of five alkaloids (nunciferine, O-nornuciferin, liriodenine, armepavine, and pronuciferine) in rat plasma was established by HPLC-MS/MS associated with micro-solid phase extraction (micro-SPE). The plasma sample was pretreat...

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Detalles Bibliográficos
Autores principales: Zou, Shuhan, Ge, Yuanyuan, Chen, Xuanhao, Li, Jin, Yang, Xuejing, Wang, Hui, Gao, Xiumei, Chang, Yan-xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817585/
https://www.ncbi.nlm.nih.gov/pubmed/31695616
http://dx.doi.org/10.3389/fphar.2019.01252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817585/
https://www.ncbi.nlm.nih.gov/pubmed/31695616
http://dx.doi.org/10.3389/fphar.2019.01252

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