Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases

Diagnosis of neurodegenerative diseases hinges on “seed” proteins detected in disease-specific aggregates. These inclusions contain diverse constituents, adhering through aberrant interactions that our prior data indicate are nonrandom. To define preferential protein-protein contacts mediating aggre...

Descripción completa

Detalles Bibliográficos
Autores principales: Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Ganne, Akshatha, Kakraba, Samuel, Penthala, Narsimha Reddy, Du, Xiuxia, Crooks, Peter A., Griffin, Sue T., Shmookler Reis, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817627/
https://www.ncbi.nlm.nih.gov/pubmed/31593839
http://dx.doi.org/10.1016/j.isci.2019.09.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817627/
https://www.ncbi.nlm.nih.gov/pubmed/31593839
http://dx.doi.org/10.1016/j.isci.2019.09.026

Ejemplares similares