Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4(KI)), based on a published mutation in patients with...

Descripción completa

Detalles Bibliográficos
Autores principales: Bullock, Whitney A., Hoggatt, April M., Horan, Daniel J., Elmendorf, Andrew J., Sato, Amy Y., Bellido, Teresita, Loots, Gabriela G., Pavalko, Fredrick M., Robling, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817631/
https://www.ncbi.nlm.nih.gov/pubmed/31585407
http://dx.doi.org/10.1016/j.isci.2019.09.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817631/
https://www.ncbi.nlm.nih.gov/pubmed/31585407
http://dx.doi.org/10.1016/j.isci.2019.09.023

Ejemplares similares