Cargando…

Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system

Diabetes has become one of the major noninfectious diseases that seriously endanger public health. The formation of islet amyloid polypeptide (IAPP) affects the normal physiological functions of the body, such as glucose metabolism and lipid metabolism. The mature human IAPP protein (hIAPP) has a st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Xiaodong, Ouyang, Hongsheng, Yu, Tingting, Chen, Xue, Pang, Daxin, Tang, Xiaochun, Chen, Chengzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817862/ https://www.ncbi.nlm.nih.gov/pubmed/31659151 http://dx.doi.org/10.1038/s41419-019-2056-5

Ejemplares similares

CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs
por: Chen, Jiahuan, et al.
Publicado: (2020)

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System
por: Wang, Kankan, et al.
Publicado: (2015)

Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing
por: Qi, Chunyun, et al.
Publicado: (2022)

Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts
por: Xie, Zicong, et al.
Publicado: (2017)

Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair
por: Wang, Kankan, et al.
Publicado: (2016)

CRISPR/Cas9-Mediated Hitchhike Expression of Functional shRNAs at the Porcine miR-17-92 Cluster
por: Lu, Chao, et al.
Publicado: (2019)

CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus
por: You, Wenni, et al.
Publicado: (2021)

Pathological alterations in the gastrointestinal tract of a porcine model of DMD
por: Zou, Xiaodong, et al.
Publicado: (2021)

Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs
por: Ruan, Jinxue, et al.
Publicado: (2015)

Large-Scale CRISPR Screen of LDLR Pathogenic Variants
por: Li, Mengjing, et al.
Publicado: (2023)

Current Status of Genetically Modified Pigs That Are Resistant to Virus Infection
por: Yuan, Hongming, et al.
Publicado: (2022)

Site-Specific Fat-1 Knock-In Enables Significant Decrease of n-6PUFAs/n-3PUFAs Ratio in Pigs
por: Li, Mengjing, et al.
Publicado: (2018)

Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus pol Genes
por: Ma, Yuyuan, et al.
Publicado: (2022)

Germ cell‐specific expression of Cre recombinase using the VASA promoter in the pig
por: Song, Yuning, et al.
Publicado: (2015)

The Advance of CRISPR-Cas9-Based and NIR/CRISPR-Cas9-Based Imaging System
por: Qiao, Huanhuan, et al.
Publicado: (2021)

MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
por: Zou, Xiaodong, et al.
Publicado: (2022)

Cholesterol Biosynthesis Modulates CSFV Replication
por: Zou, Xiaodong, et al.
Publicado: (2022)

N-3 polyunsaturated fatty acids attenuates triglyceride and inflammatory factors level in hfat-1 transgenic pigs
por: Liu, Xingxing, et al.
Publicado: (2016)

Construction and application of a CRISPR/Cas9-assisted genomic editing system for Corynebacterium glutamicum
por: Yao, Chengzhen, et al.
Publicado: (2021)

Generation and Phenotype Identification of PAX4 Gene Knockout Rabbit by CRISPR/Cas9 System
por: Xu, Yuanyuan, et al.
Publicado: (2018)

Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis
por: Zou, Xiaodong, et al.
Publicado: (2022)

CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs
por: Wu, Jun, et al.
Publicado: (2017)

Advance of genetically modified pigs in xeno-transplantation
por: Deng, Jiacheng, et al.
Publicado: (2022)

Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
por: Xin, Changchang, et al.
Publicado: (2022)

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system
por: Wang, Xianlong, et al.
Publicado: (2016)

What is CRISPR/Cas9?
por: Redman, Melody, et al.
Publicado: (2016)

Advances in CRISPR/Cas9
por: Zhu, Youmin
Publicado: (2022)

Generation of Knock-In Pigs Carrying Oct4-tdTomato Reporter through CRISPR/Cas9-Mediated Genome Engineering
por: Lai, Sisi, et al.
Publicado: (2016)

Genetically modified pigs are protected from classical swine fever virus
por: Xie, Zicong, et al.
Publicado: (2018)

CRISPR/Cas9-Mediated Integration of Large Transgene into Pig CEP112 Locus
por: Li, Guoling, et al.
Publicado: (2019)

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing
por: Duan, Li, et al.
Publicado: (2021)

Exploiting the CRISPR‐Cas9 gene‐editing system for human cancers and immunotherapy
por: Afolabi, Lukman O, et al.
Publicado: (2021)

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice
por: Wang, Jiaqi, et al.
Publicado: (2022)

Inflammation conditional genome editing mediated by the CRISPR-Cas9 system
por: Yuan, Tingting, et al.
Publicado: (2023)

Inflammation conditional genome editing mediated by the CRISPR-Cas9 system
por: Yuan, Tingting, et al.
Publicado: (2023)

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene
por: Park, Ki-Eun, et al.
Publicado: (2017)

Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9
por: Feng, Yan, et al.
Publicado: (2016)

Chromosome drives via CRISPR-Cas9 in yeast
por: Xu, Hui, et al.
Publicado: (2020)

CRISPR/Cas9 in Gastrointestinal Malignancies
por: Jefremow, André, et al.
Publicado: (2021)

CRISPR/Cas Technology in Pig-to-Human Xenotransplantation Research
por: Ryczek, Natalia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9fg4h6ai6386urqqcmfjpu3c5h