Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases

Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free heme through formation of hemozoin (β-hematin) pigment. Proteolysis of hemoglobin and formation of hemozoin are two main targ...

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Detalles Bibliográficos
Autores principales: Herraiz, Tomás, Guillén, Hugo, González-Peña, Diana, Arán, Vicente J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817881/
https://www.ncbi.nlm.nih.gov/pubmed/31659177
http://dx.doi.org/10.1038/s41598-019-51604-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817881/
https://www.ncbi.nlm.nih.gov/pubmed/31659177
http://dx.doi.org/10.1038/s41598-019-51604-z

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