Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Therapeutic activation of mitochondrial function has been suggested as an effective strategy to combat aging. Hydralazine is an FDA-approved drug used in the treatment of hypertension, heart failure and cancer. Hydralazine has been recently shown to promote lifespan in C. elegans, rotifer and yeast...

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Detalles Bibliográficos
Autores principales: Dehghan, Esmaeil, Goodarzi, Mohammad, Saremi, Bahar, Lin, Rueyling, Mirzaei, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817882/
https://www.ncbi.nlm.nih.gov/pubmed/31659167
http://dx.doi.org/10.1038/s41467-019-12425-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817882/
https://www.ncbi.nlm.nih.gov/pubmed/31659167
http://dx.doi.org/10.1038/s41467-019-12425-w

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