MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer

MicroRNAs regulate post-transcriptional gene expression and play important roles in multiple cellular processes. In this study, we found that miR-421 suppresses kelch-like ECH-associated protein 1(KEAP1) expression by targeting its 3′-untranslated region (3′UTR). A Q-PCR assay demonstrated that miR-...

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Detalles Bibliográficos
Autores principales: Duan, Fu-Gang, Wang, Mei-Fang, Cao, Ya-Bing, Dan Li, Li, Run-Ze, Fan, Xing-Xing, Khan, Imran, Lai, Huan-Ling, Zhang, Yi-Zhong, Hsiao, Wendy Wen-Luan, Yao, Xiao-Jun, Wu, Qi-Biao, Liu, Liang, Tang, Yi-Jun, Leung, Elaine Lai-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817891/
https://www.ncbi.nlm.nih.gov/pubmed/31659154
http://dx.doi.org/10.1038/s41419-019-2031-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817891/
https://www.ncbi.nlm.nih.gov/pubmed/31659154
http://dx.doi.org/10.1038/s41419-019-2031-1

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