Cargando…

MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer

MicroRNAs regulate post-transcriptional gene expression and play important roles in multiple cellular processes. In this study, we found that miR-421 suppresses kelch-like ECH-associated protein 1(KEAP1) expression by targeting its 3′-untranslated region (3′UTR). A Q-PCR assay demonstrated that miR-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duan, Fu-Gang, Wang, Mei-Fang, Cao, Ya-Bing, Dan Li, Li, Run-Ze, Fan, Xing-Xing, Khan, Imran, Lai, Huan-Ling, Zhang, Yi-Zhong, Hsiao, Wendy Wen-Luan, Yao, Xiao-Jun, Wu, Qi-Biao, Liu, Liang, Tang, Yi-Jun, Leung, Elaine Lai-Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817891/ https://www.ncbi.nlm.nih.gov/pubmed/31659154 http://dx.doi.org/10.1038/s41419-019-2031-1

Ejemplares similares

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma
por: Huang, Jun, et al.
Publicado: (2016)

Circ_MACF1 targets miR‐421 to upregulate FMO2 to suppress paclitaxel resistance and malignant cellular behaviors in lung adenocarcinoma
por: Qian, Xiaoting, et al.
Publicado: (2023)

Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer
por: Li, Yunxia, et al.
Publicado: (2018)

Novel clinical biomarkers in blood and pleural effusion for diagnosing patients with tuberculosis distinguishing from malignant tumor
por: Wang, Jian, et al.
Publicado: (2022)

miR-20b promotes growth of non-small cell lung cancer through a positive feedback loop of the Wnt/β-catenin signaling pathway
por: Ren, Tao, et al.
Publicado: (2019)

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
por: Luo, Lian-Xiang, et al.
Publicado: (2017)

Secondary findings in 421 whole exome-sequenced Chinese children
por: Chen, Wen, et al.
Publicado: (2018)

Mozart Streichquartette KV421 & 575
por: Mozart, Wolfgang Amadeus, 1756-1791

Observations of Mrk 421 with the MAGIC Telescope
por: Mazin, D
Publicado: (2005)

Evodiamine suppresses non-small cell lung cancer by elevating CD8(+) T cells and downregulating the MUC1-C/PD-L1 axis
por: Jiang, Ze-Bo, et al.
Publicado: (2020)

ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria
por: Fan, Xing-xing, et al.
Publicado: (2020)

Detection of Single Cancer Cell Multidrug Resistance With Single Cell Bioanalyzer
por: Cai, Jun, et al.
Publicado: (2023)

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation
por: Li, Run-Ze, et al.
Publicado: (2018)

Circular RNA ITCH Suppresses Cell Proliferation but Induces Apoptosis in Oral Squamous Cell Carcinoma by Regulating miR-421/PDCD4 Axis
por: Hao, Chunbo, et al.
Publicado: (2020)

Early lung cancer diagnostic biomarker discovery by machine learning methods
por: Xie, Ying, et al.
Publicado: (2020)

The key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance
por: Li, Run-Ze, et al.
Publicado: (2022)

Characteristics of CXCL2 expression in coronary atherosclerosis and negative regulation by microRNA-421
por: Yang, Jun, et al.
Publicado: (2020)

Upregulation of miR-421 predicts poor prognosis and promotes proliferation, migration, and invasion of papillary thyroid cancer cells
por: Dong, Anbing, et al.
Publicado: (2020)

Clinical significance of LSECtin and its association with PVR in non-small-cell lung cancer patients
por: Zhang, Yizhong, et al.
Publicado: (2020)

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion
por: Plouffe, Vanessa, et al.
Publicado: (2012)

MicroRNA-421 Dysregulation is Associated with Tetralogy of Fallot
por: Bittel, Douglas C., et al.
Publicado: (2014)

MicroRNA-421 Gene Polymorphism in Gastric Carcinoma
por: Jin, Xin, et al.
Publicado: (2016)

SUN-421 Leuprolide Injection Induced Pituitary Apoplexy
por: Jaggi, Shirin, et al.
Publicado: (2019)

Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways
por: Li, Lin, et al.
Publicado: (2022)

HLA-G 3’UTR polymorphism diplotypes and soluble HLA-G plasma levels impact cervical cancer susceptibility and prognosis
por: Gan, Jun, et al.
Publicado: (2022)

Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer
por: Lembo, Antonio, et al.
Publicado: (2012)

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts
por: Zheng, Yue-huan, et al.
Publicado: (2021)

A combinatorial code for mRNA 3′-UTR-mediated translational control in the mouse oocyte
por: Dai, Xing-Xing, et al.
Publicado: (2019)

Memorandum: ISR time request for an extension of the experiment R421
por: Zichichi, A
Publicado: (1982)

Large zenith angle observations of Mkn 421 with H.E.S.S
por: Horns, D
Publicado: (2005)

The Spectrum of Markarian 421 above 100 GeV with STACEE
por: Carson, J E
Publicado: (2005)

Pediatric Vancomycin Use in 421 Hospitals in the United States, 2008
por: Lasky, Tamar, et al.
Publicado: (2012)

Setting the record straight on measuring SDG 4.2.1
por: Olusanya, Bolajoko O, et al.
Publicado: (2021)

Correction to Lancet Child Adolesc Health 2020; 4: 421
Publicado: (2020)

Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans
por: Li, Ying Fei, et al.
Publicado: (2018)

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation
por: Zhang, Yi-Ze, et al.
Publicado: (2016)

Potential prognostic factors in progression-free survival for patients with cervical cancer
por: Chen, Hui-Hui, et al.
Publicado: (2021)

Widespread and extensive lengthening of 3′ UTRs in the mammalian brain
por: Miura, Pedro, et al.
Publicado: (2013)

Current Clinical Progress of PD-1/PD-L1 Immunotherapy and Potential Combination Treatment in Non–Small Cell Lung Cancer
por: Li, Jia-Xin, et al.
Publicado: (2019)

CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3′ UTR induce graying in rabbit
por: Song, Yuning, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kn7hq6hcmbccgvjruhhbr6gbs5