Inhibition of translation termination by small molecules targeting ribosomal release factors

The bacterial ribosome is an important drug target for antibiotics that can inhibit different stages of protein synthesis. Among the various classes of compounds that impair translation there are, however, no known small-molecule inhibitors that specifically target ribosomal release factors (RFs). T...

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Detalles Bibliográficos
Autores principales: Ge, Xueliang, Oliveira, Ana, Hjort, Karin, Bergfors, Terese, Gutiérrez-de-Terán, Hugo, Andersson, Dan I., Sanyal, Suparna, Åqvist, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817905/
https://www.ncbi.nlm.nih.gov/pubmed/31659219
http://dx.doi.org/10.1038/s41598-019-51977-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817905/
https://www.ncbi.nlm.nih.gov/pubmed/31659219
http://dx.doi.org/10.1038/s41598-019-51977-1

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