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The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions
Signaling by surface receptors often relies on tethered reactions whereby an enzyme bound to the cytoplasmic tail of a receptor catalyzes reactions on substrates within reach. The overall length and stiffness of the receptor tail, the enzyme, and the substrate determine a biophysical parameter terme...
Autores principales: | Zhang, Ying, Clemens, Lara, Goyette, Jesse, Allard, Jun, Dushek, Omer, Isaacson, Samuel A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818170/ https://www.ncbi.nlm.nih.gov/pubmed/31543263 http://dx.doi.org/10.1016/j.bpj.2019.08.023 |
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