Cargando…

SiRNA-Mediated RRM2 Gene Silencing Combined with Cisplatin in the Treatment of Epithelial Ovarian Cancer In Vivo: An Experimental Study of Nude Mice

Introduction: We aimed to explore small interfering (si)RNA silencing of ribonucleotide reductase M2 (RRM2) gene combined with cisplatin for the treatment of human ovarian cancer in nude mice models of subcutaneous transplantation of tumor cells. Methods: After conventional cultivation of human ovar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Ting, Wang, Liming, Li, Yong, Song, Hao, Chu, Huijun, Yang, Hongjuan, Guo, Ailian, Jiao, Jinwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818211/ https://www.ncbi.nlm.nih.gov/pubmed/31673243 http://dx.doi.org/10.7150/ijms.33979

Ejemplares similares

In vivo silencing of alpha-synuclein using naked siRNA
por: Lewis, Jada, et al.
Publicado: (2008)

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing
por: Vollmann, Elisabeth H., et al.
Publicado: (2017)

Nuclear-targeted siRNA delivery for long-term gene silencing
por: Li, Na, et al.
Publicado: (2017)

siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin
por: Zheng, Shuquan, et al.
Publicado: (2018)

The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing
por: Strapps, Walter R., et al.
Publicado: (2010)

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
por: Jayaraman, Muthusamy, et al.
Publicado: (2012)

Therapeutic siRNA silencing in inflammatory monocytes
por: Leuschner, Florian, et al.
Publicado: (2011)

An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome-protamine-DNA-siRNA complex with cell permeable peptides
por: Wang, Xin, et al.
Publicado: (2018)

Silencing of MEF2D by siRNA Loaded Selenium Nanoparticles for Ovarian Cancer Therapy
por: Wang, Changbing, et al.
Publicado: (2020)

Nanocarriers for delivery of siRNA as gene silencing mediator
por: Morales-Becerril, Aideé, et al.
Publicado: (2022)

Atelocollagen-mediated in vivo siRNA transfection in ovarian carcinoma is influenced by tumor site, siRNA target and administration route
por: Meryet-Figuière, Matthieu, et al.
Publicado: (2017)

Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice
por: Hattori, Yoshiyuki, et al.
Publicado: (2020)

Inhibition of lung tumor growth in nude mice by siRNA(CD31) targeting PECAM-1
por: OUYANG, JIN-SHENG, et al.
Publicado: (2014)

High potency silencing by single-stranded boranophosphate siRNA
por: Hall, Allison H. S., et al.
Publicado: (2006)

Primary and Secondary siRNAs in Geminivirus-induced Gene Silencing
por: Aregger, Michael, et al.
Publicado: (2012)

Chitosan Hydrogel as siRNA vector for prolonged gene silencing
por: Ma, Zhiwei, et al.
Publicado: (2014)

siRNA Versus miRNA as Therapeutics for Gene Silencing
por: Lam, Jenny K W, et al.
Publicado: (2015)

Strategies for Improving siRNA-Induced Gene Silencing Efficiency
por: Safari, Fatemeh, et al.
Publicado: (2017)

New paradigms on siRNA local application
por: Pan, Meng, et al.
Publicado: (2015)

Combination of siRNA-directed Gene Silencing With Cisplatin Reverses Drug Resistance in Human Non-small Cell Lung Cancer
por: Ganesh, Shanthi, et al.
Publicado: (2013)

Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA
por: Liu, Xiaoxia, et al.
Publicado: (2014)

Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
por: Arif, Tasleem, et al.
Publicado: (2014)

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo
por: Basha, Genc, et al.
Publicado: (2016)

Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
por: Arif, Tasleem, et al.
Publicado: (2017)

Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
por: Cui, Jiajia, et al.
Publicado: (2017)

Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina
por: Taniguchi, Takazumi, et al.
Publicado: (2020)

RORC2 Gene Silencing in Human Th17 Cells by siRNA: Design and Evaluation of Highly Efficient siRNA
por: Hakemi, Mazdak Ganjalikhani, et al.
Publicado: (2013)

An RGD-Modified MRI-Visible Polymeric Vector for Targeted siRNA Delivery to Hepatocellular Carcinoma in Nude Mice
por: Wu, Chun, et al.
Publicado: (2013)

GW body disassembly triggered by siRNAs independently of their silencing activity
por: Serman, A., et al.
Publicado: (2007)

The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci
por: Shin, Jun-Hye, et al.
Publicado: (2013)

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review
por: Wu, Jiangyu, et al.
Publicado: (2013)

Differences in silencing of mismatched targets by sliced versus diced siRNAs
por: Sun, Guihua, et al.
Publicado: (2018)

SiRNA silencing efficacy prediction based on a deep architecture
por: Han, Ye, et al.
Publicado: (2018)

siRNA Design to Silence the 3′UTR Region of Zika Virus
por: Perez-Mendez, María, et al.
Publicado: (2020)

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
por: Alshehri, Abdullah, et al.
Publicado: (2018)

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
por: Foster, Donald J., et al.
Publicado: (2018)

Progress towards in Vivo Use of siRNAs
por: Behlke, Mark A.
Publicado: (2006)

Effect of Chitosan Magnetic Nanoparticles Loaded with Ang2-siRNA Plasmids on the Growth of Melanoma Xenografts in Nude Mice
por: Shan, Xiuying, et al.
Publicado: (2020)

Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity
por: Vader, Pieter, et al.
Publicado: (2010)

Strategies for Delivery of siRNAs to Ovarian Cancer Cells
por: Farra, Rossella, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dseq197hqkmbkjakp8n4p836bk