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Molecular Simulations of Intact Anion Exchanger 1 Reveal Specific Domain and Lipid Interactions

Anion exchanger 1 (AE1) is responsible for the exchange of bicarbonate and chloride across the erythrocyte plasma membrane. Human AE1 consists of a cytoplasmic and a membrane domain joined by a 33-residue flexible linker. Crystal structures of the individual domains have been determined, but the int...

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Detalles Bibliográficos
Autores principales: De Vecchis, Dario, Reithmeier, Reinhart A.F., Kalli, Antreas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818359/
https://www.ncbi.nlm.nih.gov/pubmed/31540709
http://dx.doi.org/10.1016/j.bpj.2019.08.029