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Phylogenetic Weighting Does Little to Improve the Accuracy of Evolutionary Coupling Analyses
Homologous sequence alignments contain important information about the constraints that shape protein family evolution. Correlated changes between different residues, for instance, can be highly predictive of physical contacts within three-dimensional structures. Detecting such co-evolutionary signa...
| Autores principales: | , |
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| Format: | Online Artículo Texto |
| Sprog: | English |
| Udgivet: |
MDPI
2019
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| Fag: | |
| Online adgang: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818970/ https://www.ncbi.nlm.nih.gov/pubmed/31662602 http://dx.doi.org/10.3390/e21101000 |