Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease

We report a signaling pathway linking two fundamental functions of the ER, oxidative protein folding, and intracellular calcium regulation. Cells sense ER oxidative protein folding through H(2)O(2,) which induces Nrf2 nuclear translocation. Nrf2 regulates the expression of GPx8, an ER glutathione pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Granatiero, Veronica, Konrad, Csaba, Bredvik, Kirsten, Manfredi, Giovanni, Kawamata, Hibiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819749/
https://www.ncbi.nlm.nih.gov/pubmed/31658977
http://dx.doi.org/10.26508/lsa.201900563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819749/
https://www.ncbi.nlm.nih.gov/pubmed/31658977
http://dx.doi.org/10.26508/lsa.201900563

Ejemplares similares