2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells

2-Methylthio-N(6)-isopentenyl modification of adenosine (ms(2)i(6)A) is an evolutionally conserved modification found in mitochondrial (mt)-tRNAs. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1) specifically converts N6-isopentenyladenosine (i(6)A) to ms(2)i(6)A at position A37 of four mt-DN...

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Detalles Bibliográficos
Autores principales: Yamamoto, Takahiro, Fujimura, Atsushi, Wei, Fan-Yan, Shinojima, Naoki, Kuroda, Jun-ichiro, Mukasa, Akitake, Tomizawa, Kazuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820277/
https://www.ncbi.nlm.nih.gov/pubmed/31654853
http://dx.doi.org/10.1016/j.isci.2019.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820277/
https://www.ncbi.nlm.nih.gov/pubmed/31654853
http://dx.doi.org/10.1016/j.isci.2019.10.012

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