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Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature

Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including...

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Detalles Bibliográficos
Autores principales: Koufopoulos, Nektarios, Antoniadou, Foteini, Kokkali, Stefania, Pigadioti, Eleni, Khaldi, Lubna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820319/
https://www.ncbi.nlm.nih.gov/pubmed/31695973
http://dx.doi.org/10.7759/cureus.5550
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author Koufopoulos, Nektarios
Antoniadou, Foteini
Kokkali, Stefania
Pigadioti, Eleni
Khaldi, Lubna
author_facet Koufopoulos, Nektarios
Antoniadou, Foteini
Kokkali, Stefania
Pigadioti, Eleni
Khaldi, Lubna
author_sort Koufopoulos, Nektarios
collection PubMed
description Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including the classic, solid, signet ring cell, tubulolobular, alveolar, trabecular, pleomorphic, and mixed subtypes each one with a distinctive morphology. Invasive lobular carcinoma has been associated with intracellular mucin production, in the form of intracytoplasmic lumina and signet ring cells whereas extracellular mucin production has been related to carcinomas of ductal origin. A new variant that displays extracellular mucin production was described recently. Only nineteen cases of this rare entity have been reported to date. In this manuscript, we report an additional case of invasive lobular carcinoma with extracellular mucin production, describing its clinico-pathological characteristics, and review the literature on the same.
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spelling pubmed-68203192019-11-06 Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature Koufopoulos, Nektarios Antoniadou, Foteini Kokkali, Stefania Pigadioti, Eleni Khaldi, Lubna Cureus Oncology Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including the classic, solid, signet ring cell, tubulolobular, alveolar, trabecular, pleomorphic, and mixed subtypes each one with a distinctive morphology. Invasive lobular carcinoma has been associated with intracellular mucin production, in the form of intracytoplasmic lumina and signet ring cells whereas extracellular mucin production has been related to carcinomas of ductal origin. A new variant that displays extracellular mucin production was described recently. Only nineteen cases of this rare entity have been reported to date. In this manuscript, we report an additional case of invasive lobular carcinoma with extracellular mucin production, describing its clinico-pathological characteristics, and review the literature on the same. Cureus 2019-09-01 /pmc/articles/PMC6820319/ /pubmed/31695973 http://dx.doi.org/10.7759/cureus.5550 Text en Copyright © 2019, Koufopoulos et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Koufopoulos, Nektarios
Antoniadou, Foteini
Kokkali, Stefania
Pigadioti, Eleni
Khaldi, Lubna
Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
title Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
title_full Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
title_fullStr Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
title_full_unstemmed Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
title_short Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
title_sort invasive lobular carcinoma with extracellular mucin production: description of a case and review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820319/
https://www.ncbi.nlm.nih.gov/pubmed/31695973
http://dx.doi.org/10.7759/cureus.5550
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