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Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature
Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820319/ https://www.ncbi.nlm.nih.gov/pubmed/31695973 http://dx.doi.org/10.7759/cureus.5550 |
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author | Koufopoulos, Nektarios Antoniadou, Foteini Kokkali, Stefania Pigadioti, Eleni Khaldi, Lubna |
author_facet | Koufopoulos, Nektarios Antoniadou, Foteini Kokkali, Stefania Pigadioti, Eleni Khaldi, Lubna |
author_sort | Koufopoulos, Nektarios |
collection | PubMed |
description | Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including the classic, solid, signet ring cell, tubulolobular, alveolar, trabecular, pleomorphic, and mixed subtypes each one with a distinctive morphology. Invasive lobular carcinoma has been associated with intracellular mucin production, in the form of intracytoplasmic lumina and signet ring cells whereas extracellular mucin production has been related to carcinomas of ductal origin. A new variant that displays extracellular mucin production was described recently. Only nineteen cases of this rare entity have been reported to date. In this manuscript, we report an additional case of invasive lobular carcinoma with extracellular mucin production, describing its clinico-pathological characteristics, and review the literature on the same. |
format | Online Article Text |
id | pubmed-6820319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-68203192019-11-06 Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature Koufopoulos, Nektarios Antoniadou, Foteini Kokkali, Stefania Pigadioti, Eleni Khaldi, Lubna Cureus Oncology Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including the classic, solid, signet ring cell, tubulolobular, alveolar, trabecular, pleomorphic, and mixed subtypes each one with a distinctive morphology. Invasive lobular carcinoma has been associated with intracellular mucin production, in the form of intracytoplasmic lumina and signet ring cells whereas extracellular mucin production has been related to carcinomas of ductal origin. A new variant that displays extracellular mucin production was described recently. Only nineteen cases of this rare entity have been reported to date. In this manuscript, we report an additional case of invasive lobular carcinoma with extracellular mucin production, describing its clinico-pathological characteristics, and review the literature on the same. Cureus 2019-09-01 /pmc/articles/PMC6820319/ /pubmed/31695973 http://dx.doi.org/10.7759/cureus.5550 Text en Copyright © 2019, Koufopoulos et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Oncology Koufopoulos, Nektarios Antoniadou, Foteini Kokkali, Stefania Pigadioti, Eleni Khaldi, Lubna Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature |
title | Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature |
title_full | Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature |
title_fullStr | Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature |
title_full_unstemmed | Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature |
title_short | Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature |
title_sort | invasive lobular carcinoma with extracellular mucin production: description of a case and review of the literature |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820319/ https://www.ncbi.nlm.nih.gov/pubmed/31695973 http://dx.doi.org/10.7759/cureus.5550 |
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