MD-1 Deficiency Accelerates Myocardial Inflammation and Apoptosis in Doxorubicin-Induced Cardiotoxicity by Activating the TLR4/MAPKs/Nuclear Factor kappa B (NF-κB) Signaling Pathway

BACKGROUND: Myocardial apoptosis and inflammation play important roles in doxorubicin (DOX)-caused cardiotoxicity. Our prior studies have characterized the effects of myeloid differentiation protein 1(MD-1) in pathological cardiac remodeling and myocardial ischemia/reperfusion (I/R) injury, but its...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ying-Jun, Huang, He, Liu, Yu, Kong, Bin, Wang, Guangji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Animal Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820359/
https://www.ncbi.nlm.nih.gov/pubmed/31636246
http://dx.doi.org/10.12659/MSM.919861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820359/
https://www.ncbi.nlm.nih.gov/pubmed/31636246
http://dx.doi.org/10.12659/MSM.919861

Ejemplares similares