Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway

APOL1 alleles G1 and G2 are associated with faster progression to lupus nephritis (LN)-associated end-stage renal disease (LN-ESRD) in African Americans. Increased levels of type I interferons (IFNs) and nucleosome-associated double-stranded DNA (dsDNA) fragments (nsDNA) are the hallmark of this dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Shamara E., Khatua, Atanu K., Popik, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820523/
https://www.ncbi.nlm.nih.gov/pubmed/31664093
http://dx.doi.org/10.1038/s41598-019-51998-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820523/
https://www.ncbi.nlm.nih.gov/pubmed/31664093
http://dx.doi.org/10.1038/s41598-019-51998-w

Ejemplares similares