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Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Synonymous codons occur with different frequencies in different organisms, a phenomenon termed codon usage bias. Codon optimization, a common term for a variety of approaches used widely by the biopharmaceutical industry, involves synonymous substitutions to increase protein expression. It had long...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820528/ https://www.ncbi.nlm.nih.gov/pubmed/31664102 http://dx.doi.org/10.1038/s41598-019-51984-2 |