Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism

Emerging evidences suggest that phospholipid metabolism is altered in Alzheimer’s disease (AD), but molecular mechanisms on how this affects neurodegeneration in AD is poorly understood. SHIP2 is a phosphoinositide-metabolizing enzyme, which dephosphorylates PI(3,4,5)P(3) resulting to PI(3,4)P(2), a...

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Detalles Bibliográficos
Autores principales: Lee, Hae Nim, Sim, Kyoung Mi, Kim, Hyunbin, Ju, Jeongmin, Pae, Ae Nim, Park, Jae-Bong, Ryu, Hoon, Seong, Jihye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820556/
https://www.ncbi.nlm.nih.gov/pubmed/31664099
http://dx.doi.org/10.1038/s41598-019-51914-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820556/
https://www.ncbi.nlm.nih.gov/pubmed/31664099
http://dx.doi.org/10.1038/s41598-019-51914-2

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