Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography

The lipid A biosynthesis pathway is essential in Pseudomonas aeruginosa. LpxA and LpxD are the first and third enzymes in this pathway respectively, and are regarded as promising antibiotic targets. The unique structural similarities between these two enzymes make them suitable targets for dual-bind...

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Detalles Bibliográficos
Autores principales: Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820557/
https://www.ncbi.nlm.nih.gov/pubmed/31664082
http://dx.doi.org/10.1038/s41598-019-51844-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820557/
https://www.ncbi.nlm.nih.gov/pubmed/31664082
http://dx.doi.org/10.1038/s41598-019-51844-z

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