A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice

Pathological tau correlates well with cognitive impairments in Alzheimer’s disease (AD) patients and therefore represents a promising target for immunotherapy. Targeting an appropriate B cell epitope in pathological tau could in theory produce an effective reduction of pathology without disrupting t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hovakimyan, Armine, Antonyan, Tatevik, Shabestari, Sepideh Kiani, Svystun, Olga, Chailyan, Gor, Coburn, Morgan A., Carlen-Jones, William, Petrushina, Irina, Chadarevian, Jean Paul, Zagorski, Karen, Petrovsky, Nikolai, Cribbs, David H., Agadjanyan, Michael G., Ghochikyan, Anahit, Davtyan, Hayk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820729/
https://www.ncbi.nlm.nih.gov/pubmed/31664089
http://dx.doi.org/10.1038/s41598-019-51809-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820729/
https://www.ncbi.nlm.nih.gov/pubmed/31664089
http://dx.doi.org/10.1038/s41598-019-51809-2

Ejemplares similares