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Leu(8) and Pro(8) oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors

Oxytocin (OXT) is an important neuromodulator of social behaviors via activation of both oxytocin receptors (OXTR) and vasopressin (AVP) 1a receptors (AVPR1a). Marmosets are neotropical primates with a modified OXT ligand (Pro(8)-OXT), and this ligand shows significant coevolution with traits includ...

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Detalles Bibliográficos
Autores principales: Mustoe, Aaryn, Schulte, Nancy A., Taylor, Jack H., French, Jeffrey A., Toews, Myron L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820730/
https://www.ncbi.nlm.nih.gov/pubmed/31664130
http://dx.doi.org/10.1038/s41598-019-52024-9