Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody

Single-domain antibodies (VHHs or nanobodies), developed from heavy chain-only antibodies of camelids, are gaining attention as next-generation therapeutic agents. Despite their small size, the high affinity and specificity displayed by VHHs for antigen molecules rival those of IgGs. How such small...

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Detalles Bibliográficos
Autores principales: Akiba, Hiroki, Tamura, Hiroko, Kiyoshi, Masato, Yanaka, Saeko, Sugase, Kenji, Caaveiro, Jose M. M., Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820745/
https://www.ncbi.nlm.nih.gov/pubmed/31664051
http://dx.doi.org/10.1038/s41598-019-50722-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820745/
https://www.ncbi.nlm.nih.gov/pubmed/31664051
http://dx.doi.org/10.1038/s41598-019-50722-y

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