Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples

It is extremely expensive to conduct large sample size array- or sequencing based genome scale association studies. For a quantitative trait, an extreme case-control study design may improve the power and reduce the cost of variant calling. We investigated the performance of extreme study design whe...

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Detalles Bibliográficos
Autores principales: Li, Yi, Levran, Orna, Kim, JongJoo, Zhang, Tiejun, Chen, Xingdong, Suo, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820758/
https://www.ncbi.nlm.nih.gov/pubmed/31664079
http://dx.doi.org/10.1038/s41598-019-51790-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820758/
https://www.ncbi.nlm.nih.gov/pubmed/31664079
http://dx.doi.org/10.1038/s41598-019-51790-w

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