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Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples
It is extremely expensive to conduct large sample size array- or sequencing based genome scale association studies. For a quantitative trait, an extreme case-control study design may improve the power and reduce the cost of variant calling. We investigated the performance of extreme study design whe...
Autores principales: | Li, Yi, Levran, Orna, Kim, JongJoo, Zhang, Tiejun, Chen, Xingdong, Suo, Chen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820758/ https://www.ncbi.nlm.nih.gov/pubmed/31664079 http://dx.doi.org/10.1038/s41598-019-51790-w |
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