Uremic serum residue decreases SN-38 sensitivity through suppression of organic anion transporter polypeptide 2B1 in LS-180 colon cancer cells

Pharmacokinetics of SN-38 in patients with end-stage kidney disease (ESKD) is partially varied because of fluctuations in transporters expression and/or function by high protein bound-uremic toxins concentration. The fluctuations may induce variations in anticancer drugs sensitivity to cancer cells....

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Detalles Bibliográficos
Autores principales: Ozawa, Shoichi, Tsujimoto, Masayuki, Uchiyama, Hitoshi, Ito, Natsuko, Morishita, Satoe, Yamamoto, Mizuki, Irie, Ryosuke, Sakashita, Tohko, Tachiki, Hidehisa, Furukubo, Taku, Izumi, Satoshi, Yamakawa, Tomoyuki, Minegaki, Tetsuya, Nishiguchi, Kohshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820778/
https://www.ncbi.nlm.nih.gov/pubmed/31664047
http://dx.doi.org/10.1038/s41598-019-51640-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820778/
https://www.ncbi.nlm.nih.gov/pubmed/31664047
http://dx.doi.org/10.1038/s41598-019-51640-9

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