CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation

BACKGROUND: The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome-wide association studies (GWAS) have identified hundreds of genec susceptibili...

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Detalles Bibliográficos
Autores principales: Cook, Naomi L., Pjanic, Milos, Emmerich, Andrew G., Rao, Abhiram S., Hetty, Susanne, Knowles, Joshua W., Quertermous, Thomas, Castillejo-López, Casimiro, Ingelsson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820957/
https://www.ncbi.nlm.nih.gov/pubmed/31664995
http://dx.doi.org/10.1186/s12902-019-0442-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820957/
https://www.ncbi.nlm.nih.gov/pubmed/31664995
http://dx.doi.org/10.1186/s12902-019-0442-8

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