G-quadruplex located in the 5′UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance

The anti-apoptotic BAG-1 protein isoforms are known to be overexpressed in colorectal tumors and are considered to be potential therapeutic targets. The isoforms are derived from alternative translation initiations occuring at four in-frame start codons of a single mRNA transcript. Its 5′UTR also co...

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Detalles Bibliográficos
Autores principales: Jodoin, Rachel, Carrier, Julie C, Rivard, Nathalie, Bisaillon, Martin, Perreault, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821271/
https://www.ncbi.nlm.nih.gov/pubmed/31504805
http://dx.doi.org/10.1093/nar/gkz777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821271/
https://www.ncbi.nlm.nih.gov/pubmed/31504805
http://dx.doi.org/10.1093/nar/gkz777

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