Cargando…
G-quadruplex located in the 5′UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance
The anti-apoptotic BAG-1 protein isoforms are known to be overexpressed in colorectal tumors and are considered to be potential therapeutic targets. The isoforms are derived from alternative translation initiations occuring at four in-frame start codons of a single mRNA transcript. Its 5′UTR also co...
Autores principales: | Jodoin, Rachel, Carrier, Julie C, Rivard, Nathalie, Bisaillon, Martin, Perreault, Jean-Pierre |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821271/ https://www.ncbi.nlm.nih.gov/pubmed/31504805 http://dx.doi.org/10.1093/nar/gkz777 |
Ejemplares similares
-
Cap-independent translation through the p27 5′-UTR
por: Jiang, Hong, et al.
Publicado: (2007) -
5′-UTR G-quadruplex structures acting as translational repressors
por: Beaudoin, Jean-Denis, et al.
Publicado: (2010) -
G-quadruplexes formation in the 5’UTRs of mRNAs associated with colorectal cancer pathways
por: Jodoin, Rachel, et al.
Publicado: (2018) -
3′ UTR G-quadruplexes regulate miRNA binding
por: Rouleau, Samuel, et al.
Publicado: (2017) -
Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening
por: Beaudoin, Jean-Denis, et al.
Publicado: (2013)