Cargando…

KMS99220 Exerts Anti-Inflammatory Effects, Activates the Nrf2 Signaling and Interferes with IKK, JNK and p38 MAPK via HO-1

Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson’s disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters the brain, exerts neuroprotective effect, and inhibits NF-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Ji Ae, Kim, Dong Jin, Hwang, Onyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821456/ https://www.ncbi.nlm.nih.gov/pubmed/31656063 http://dx.doi.org/10.14348/molcells.2019.0129

Ejemplares similares

The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
por: Lee, Ji Ae, et al.
Publicado: (2018)

The KMS State of Space-Time at the Planck Scale
por: Bogdanoff, I
Publicado: (2001)

Derivations and KMS-Symmetric Quantum Markov Semigroups
por: Vernooij, Matthijs, et al.
Publicado: (2023)

Propofol Induces the Expression of Nrf2 and HO-1 in Echinococcus granulosus via the JNK and p38 Pathway In Vitro
por: Luo, Guangyi, et al.
Publicado: (2023)

Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain
por: Yang, Yang, et al.
Publicado: (2022)

Dehydrocostus lactone inhibits NFATc1 via regulation of IKK, JNK, and Nrf2, thereby attenuating osteoclastogenesis
por: Lee, Hye In, et al.
Publicado: (2020)

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
por: Pua, Lesley Jia Wei, et al.
Publicado: (2022)

Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway
por: Ebrahimpour, Afshin, et al.
Publicado: (2021)

Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
por: Lv, Hongming, et al.
Publicado: (2016)

Data on the phosphorylation of p38MAPK and JNK induced by chlorpyrifos in Drosophila melanogaster
por: Batista, J.E.S., et al.
Publicado: (2016)

A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation
por: Liu, Xin, et al.
Publicado: (2016)

Anti-Inflammatory Effects of Secondary Metabolites of Marine Pseudomonas sp. in Human Neutrophils Are through Inhibiting P38 MAPK, JNK, and Calcium Pathways
por: Yang, Shun-Chin, et al.
Publicado: (2014)

Protective effect of Anwulignan against D-galactose-induced hepatic injury through activating p38 MAPK–Nrf2–HO-1 pathway in mice
por: Gao, Jiaqi, et al.
Publicado: (2018)

A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects
por: Lee, Ji Ae, et al.
Publicado: (2022)

Draft Genome Sequence of Pseudomonas stutzeri Strain KMS 55, an Endophytic Diazotroph Isolated from Rice Roots
por: Annapurna, Kannepalli, et al.
Publicado: (2017)

Physiochemical, sensorial and rheological characteristics of puree developed from Kashmiri peaches: influence of sugar, KMS and storage conditions
por: Wani, Shefali, et al.
Publicado: (2021)

The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells
por: Zhu, Liqian, et al.
Publicado: (2016)

Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways
por: Yang, Zhangshuo, et al.
Publicado: (2022)

Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts
por: Hao, Qianyun, et al.
Publicado: (2020)

Paeoniflorin Resists H(2)O(2)-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway
por: Yuan, Jinping, et al.
Publicado: (2020)

The Increase of ROS Caused by the Interference of DEHP with JNK/p38/p53 Pathway as the Reason for Hepatotoxicity
por: Huang, Yuanyuan, et al.
Publicado: (2019)

Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK-Dependent ROS
por: Lee, Sei Young, et al.
Publicado: (2014)

Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways
por: Wang, Shan, et al.
Publicado: (2018)

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway
por: Yang, Xiaorong, et al.
Publicado: (2018)

Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation
por: Subedi, Lalita, et al.
Publicado: (2019)

Diosmin Mitigates Gentamicin-Induced Nephrotoxicity in Rats: Insights on miR-21 and -155 Expression, Nrf2/HO-1 and p38-MAPK/NF-κB Pathways
por: Nadeem, Rania I., et al.
Publicado: (2023)

Flavonoids from Engineered Tomatoes Inhibit Gut Barrier Pro-inflammatory Cytokines and Chemokines, via SAPK/JNK and p38 MAPK Pathways
por: Tomlinson, Matthew L., et al.
Publicado: (2017)

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC
por: Chan, Leong-Perng, et al.
Publicado: (2017)

CB1 enhanced the osteo/dentinogenic differentiation ability of periodontal ligament stem cells via p38 MAPK and JNK in an inflammatory environment
por: Yan, Wanhao, et al.
Publicado: (2019)

Sec-O-glucosylhamaudol mitigates inflammatory processes and autophagy via p38/JNK MAPK signaling in a rat neuropathic pain model
por: Oh, Seon Hee, et al.
Publicado: (2021)

Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway
por: Niu, Tingting, et al.
Publicado: (2020)

Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
por: Wen, Yi-Ling, et al.
Publicado: (2021)

Attenuation of Oxidative Damage via Upregulating Nrf2/HO-1 Signaling Pathway by Protease SH21 with Exerting Anti-Inflammatory and Anticancer Properties In Vitro
por: Tarek, Hasan, et al.
Publicado: (2023)

Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation
por: NaveenKumar, Somanathapura K., et al.
Publicado: (2015)

Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells
por: Chan, Chim-Kei, et al.
Publicado: (2017)

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways
por: Pang, Xiaojun, et al.
Publicado: (2021)

Dexamethasone Induces Apoptosis of Nasal Polyp-Derived Tissue Cultures Through JNK and p38 MAPK Activation
por: Lee, Tae-Hoon, et al.
Publicado: (2014)

Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways
por: Liu, Haojie, et al.
Publicado: (2017)

High glucose promotes annulus fibrosus cell apoptosis through activating the JNK and p38 MAPK pathways
por: Shan, Lizhen, et al.
Publicado: (2019)

A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing
por: Lanna, Alessio, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6je76rmlg0fi4pkc5bds26ldum