Cargando…

Notch Signaling Regulates MMP-13 Expression via Runx2 in Chondrocytes

Notch signaling is involved in the early onset of osteoarthritis. The aim of this study was to investigate the role of Notch signaling changes during proliferation and differentiation of chondrocyte, and to testify the mechanism of MMP-13 regulation by Notch and Runx2 expression changes during osteo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Di, Bi, Ruiye, Liu, Xianwen, Mei, Jie, Jiang, Nan, Zhu, Songsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821756/ https://www.ncbi.nlm.nih.gov/pubmed/31666602 http://dx.doi.org/10.1038/s41598-019-52125-5

Ejemplares similares

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes
por: Takahashi, Atsushi, et al.
Publicado: (2017)

Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling
por: Wang, Jen-Jui, et al.
Publicado: (2012)

The Dual Role of Small Extracellular Vesicles in Joint Osteoarthritis: Their Global and Non-Coding Regulatory RNA Molecule-Based Pathogenic and Therapeutic Effects
por: Li, Zhi, et al.
Publicado: (2023)

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
por: Qin, Xin, et al.
Publicado: (2020)

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes
por: Baker, Jonathan, et al.
Publicado: (2018)

Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling
por: Yang, Yueyi, et al.
Publicado: (2021)

Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1
por: Lehtola, Tiina, et al.
Publicado: (2022)

Comparison of early-stage changes of osteoarthritis in cartilage and subchondral bone between two different rat models
por: Yang, Yutao, et al.
Publicado: (2020)

The accuracy of three-dimensional rapid prototyped surgical template guided anterior segmental osteotomy
por: Qu, Moyuan, et al.
Publicado: (2019)

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9
por: Kohn, Anat, et al.
Publicado: (2015)

Semaphorin 3A-Neuropilin-1 Signaling Modulates MMP13 Expression in Human Osteoarthritic Chondrocytes
por: Stöckl, Sabine, et al.
Publicado: (2022)

Near-Infrared Light-Activated Mesoporous Polydopamine for Temporomandibular Joint Osteoarthritis Combined Photothermal-Chemo Therapy
por: Li, Qianli, et al.
Publicado: (2023)

Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes
por: Huang, Wenzhou, et al.
Publicado: (2017)

Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest
por: Shang, Xifu, et al.
Publicado: (2016)

RUNX2 promotes gastric cancer progression through the transcriptional activation of MGAT5 and MMP13
por: Wang, Ying, et al.
Publicado: (2023)

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes
por: Ma, Ching-Hou, et al.
Publicado: (2017)

The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis
por: Terauchi, Koh, et al.
Publicado: (2016)

Upregulated MMP28 in Hepatocellular Carcinoma Promotes Metastasis via Notch3 Signaling and Predicts Unfavorable Prognosis
por: Zhou, Jiangfan, et al.
Publicado: (2019)

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development
por: Nagata, Kosei, et al.
Publicado: (2022)

Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study
por: Wang, Ruiyu, et al.
Publicado: (2022)

E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes
por: Liang, Yujie, et al.
Publicado: (2016)

Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation
por: Jiang, Yi Na, et al.
Publicado: (2015)

Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis
por: Jiang, Qing, et al.
Publicado: (2020)

Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents
por: Sirikaew, Nutnicha, et al.
Publicado: (2019)

Fibrocartilage Stem Cells in the Temporomandibular Joint: Insights From Animal and Human Studies
por: Fan, Yi, et al.
Publicado: (2021)

Regulatory role of human fibrocartilage stem cells in condyle osteochondroma
por: Yin, Qing, et al.
Publicado: (2022)

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9
por: Chen, Shan, et al.
Publicado: (2013)

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
por: Fujita, Takashi, et al.
Publicado: (2004)

Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes
por: Orfanidou, Timoklia, et al.
Publicado: (2009)

RUNX2 facilitates aggressiveness and chemoresistance of triple negative breast cancer cells via activating MMP1
por: Si, Wentao, et al.
Publicado: (2022)

Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice
por: Liao, Lifan, et al.
Publicado: (2017)

Pleiotropic Roles of NOTCH1 Signaling in the Loss of Maturational Arrest of Human Osteoarthritic Chondrocytes
por: Minguzzi, Manuela, et al.
Publicado: (2021)

Notch Signaling Regulates the Chondrogenic Potential of Both Articular Chondrocytes and Their Progenitors During Expansion
por: Kurenkova, Anastasiia D, et al.
Publicado: (2023)

Long noncoding RNA TUG1 regulates degradation of chondrocyte extracellular matrix via miR-320c/MMP-13 axis in osteoarthritis
por: Han, Hu, et al.
Publicado: (2021)

DLK1 Promotes Lung Cancer Cell Invasion through Upregulation of MMP9 Expression Depending on Notch Signaling
por: Li, Lin, et al.
Publicado: (2014)

Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes
por: Jung, Youn-Kwan, et al.
Publicado: (2019)

Long non-coding ribonucleic acid AFAP1-AS1 promotes chondrocyte proliferation via the miR-512-3p/matrix metallopeptidase 13 (MMP-13) axis
por: Zhao, Zhi, et al.
Publicado: (2022)

Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes
por: Bonyadi Rad, Ehsan, et al.
Publicado: (2017)

Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways
por: Gao, Feixia, et al.
Publicado: (2018)

Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes
por: Rousset, Francis, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1tcaa44rubbv61mmddtg6ge36v